Rachel Bilson (Dr. Zoe Hart)Jaime King (Lemon Breeland)Cress Williams (Lavon Hayes)Wilson Bethel (Wade Kinsella)Scott Porter (George Tucker)Tim Matheson (Dr. Brick Breeland)Kaitlyn Black (AnnaBeth Nass)Ross Philips (Tom Long)Mallory Moye (Wanda Long)Reginald VelJohnson (Dash DeWitt)Brandi Burkhardt (Crickett)Claudia Lee (Magnolia Breeland)Matt Lowe (Meatball)John Eric Bentley (Sheriff Bill)Armelia McQueen (Shula)Mircea Monroe (Tansy Truitt)Laura Bell Bundy (Shelby Sinclair)Steven M. Porter (Frank Moth)
David Babcock, April Blair, Debra Fordham, Sheila Lawrence, Ari Posner, Alex Taub, Donald Todd, Michelle Paradise, Rina Mimoun, Sarah Kucserka, Jamie Gorenberg, Tamar Laddy, Leila Gerstein, Veronica West, Amy Roy, Carter Covington, Beth Schwartz, Alex Katsnelson, Adam Milch, Len Goldstein, Dan Steele, Kendall Sand
New Yorker and new doctor Zoe Hart accepts an offer from a stranger, Dr. Harley Wilkes, to work in his medical practice in Bluebell, Alabama. She arrives to find that he has died and left half the practice to her in his will.